The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide induced squamous cell carcinoma of the tongue in ratsInternational Journal of Oral and Maxillofacial Surgery


S. Cubuk, S. Uckan, H. Ozdemir, F.Z. Taslica, D. Bacanli
Surgery / Oral Surgery / Otorhinolaryngology


Max born medal and prize

The Institute of Physics

Rape in marriage

Lee H. Bowker, o̊Dean of the Graduate School and Research


e50 Oral Presentation

Bone distraction gives good results, but bone-borne devices are space-occupying and uncomfortable.

Objectives: To present treatment of vertical bone atrophy in aesthetically important sites via tooth/implant-borne distraction.

Methods: Soft tissue incision is located high in the buccal fornix and alveolar bone is osteotomized. Distraction device is an orthodontic screw anchored to dental arch, applying force on teeth or implants in the distraction fragment. After vertical overcorrection, the bone block is fixed in the new position with orthodontic ligatures and distraction device removed. Implants are inserted and a vestibuloplasty restores attached mucosa.

Findings and conclusions: In the last 5 years 10 osteodistractions on edentulous premaxilla were performed.

No complications were registered and the bone fragment could always be transported in the desired position. In cases of simultaneous transversal atrophy, homologous bone graft was inserted.

Final prosthetic rehabilitation was always judged acceptable by patients and referent dentists.

The efficiency of propranolol on occurrence and development of 4-nitroquinoline 1-oxide induced squamous cell carcinoma of the tongue in rats

S. Cubuk 1,∗, S. Uckan 1, H. Ozdemir 2, F.Z. Taslica 2,

D. Bacanli 2 1 Medipol University, Istanbul, Turkey 2 Baskent University, Ankara, Turkey

Background: Oral cavity cancers are one of the most frequent neoplasms. Previously reported study showed that propranolol can be effective for prevention of cancer development or anticancer therapies.

Objective: The aim of this study was to investigate the efficiency of propranolol on 4NQO induced squamous cell carcinogenesis of the tongue in rats.

Methods: Twenty-seven male Sprague Dawley rats were received 50 ppm 4NQO for 20 weeks in drinking water. Group 1, gained propranolol by oral gavage; Group 2, following to carcinogesis inducement for 20 weeks, propranolol were applied for 2 weeks; Group 3, no treatment was applied. Tongue specimens were evaluated under light microscope and categorized as low or high risky lesions according to binary system.

Findings: Histopathological analysis revealed decreased risk of malignant transformation rates in Group 1 (33.3%) when compared with Group 2 (55.5%) and 3 (77.8%). There were slightly difference between 3 groups regarding to high risk category (Group 1; 11.1%, Groups 2 and 3; 22.2%) The rates of low risk category were 22.2% in Group 1, 33.3% in Group 2,55.5% in Group 3. Though the difference between groups was not statistically significant. (P > 0.05). One tumor occurrence was detected for each group. Tumor size in Group 3 (1.8 cm) was almost threefold of the sample in Group 1 (0.6 cm).

Conclusions:As we concluded propranolol usage may provide chemoprevention in early carcinogenesis stages.

Predictability and accuracy of hard and soft tissue positioning post bilateral sagittal split osteotomy for the advancement of the mandible

S. Dahiya ∗, M. Padhye, Y. Kini, G. Madiwale, P. Mehtal,

K. Vij, P. Pardeshi

D.Y. Patil University School of Dentistry, Navi, Mumbai, India

Background: It is important to know the accuracy of prediction tracings, as compared to the actual outcome of BSSO for the advancement of the mandible. Also important is to know if this outcome remains stable post surgery.

Objectives: The purpose of this retrospective study was to compare the prediction tracings to the actual outcome of BSSO for advancement of the mandible.

Methods: 15 patients (mean age 23 years) with mandibular hyperplasia who required orthognathic correction, had prospective and consecutive planning and treatment. All patients had preoperative orthodontic treatment, orthognathic surgery, and postoperative orthodontic treatment. Clinical photographs, study models mounted on an articulator, and standardized lateral cephalometric radiographs were obtained preoperatively, after one month post operatively and six months postoperatively.

Findings and results: In 82% cases excellent correlation between the predicted and actual mandibular positions in vertical and horizontal dimensions was seen. In the remaining cases there were changes in the dimensions post operatively but the overall result was acceptable for the clinician and the patient.

Osteoradionecrosis, an increasing indication for osseous microvascular maxillomandibular reconstruction

D. Danielsson 1,3,∗, E. Munck-Wikland 1, M. Halle 2 1 Department of Clinical Science, Intervention and Technology,

Division of ENT Diseases, Karolinska Institute, Stockholm,

Sweden 2 Department of Molecular Medicine and Surgery,

Reconstructive Plastic Surgery, Karolinska Institute and

Karolinska University Hospital, Stockholm, Sweden 3 Department of Oral and Maxillofacial Surgery, Karolinska

University Hospital, Stockholm, Sweden

Objectives: Investigate the role of ORN as cause to changing indications for maxillomandibular reconstructive surgery at

Karolinska University Hospital.

Methods: Retrospecitve chart study. Review of all patients who underwent maxillo-mandibular reconstruction with vascularized free bone flaps between 1995 and 2012 at Karolinska

University Hospital.

Findings: A total of 240 patients who had received free flaps were identified and out of which 80 flaps were osseous free flaps. The most common indications for surgery were squamous cell carcinoma, SCC, (n = 160), and osteoradionecrosis, ORN, (n = 44). Other indications included other types of malignant tumors, benign tumors and gunshot wounds. Mean age was 59.5 years of age (range 5–86 years). In our material 65% were men and 35% women.

ORN cases represented 9% of the total number of microvascular reconstructions performed from 1995 to 2000, 17% during the period from 2001 to 2006 and 27% of the cases between 2007 and 2012.