Equine endometrial biopsy reviewed: Observation, interpretation, and application of histopathologic dataTheriogenology

About

Authors
T.A. Snider, C. Sepoy, G.R. Holyoak
Year
2011
DOI
10.1016/j.theriogenology.2010.12.013
Subject
Equine / Food Animals / Small Animals / Animal Science and Zoology

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Available online at www.sciencedirect.com 009 doiReview quine endometrial biopsy reviewed: Observation, interpretation, and application of histopathologic data

T.A. Snidera, C. Sepoyb, G.R. Holyoakb,* a Department of Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA b Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA

Received 13 May 2008; received in revised form 20 December 2010; accepted 21 December 2010 stract

The equine endometrial biopsy, an important tool in equine reproduction science, has experienced a rich period of increasing owledge, development, and application over the past 40 y. Much of the foundational work in this field was conducted by Dr. bert M. Kenney. In view of his recent passing, this review is dedicated to our alumnus, Dr. Robert M. Kenney (OSU, 1954). this manuscript, we pay tribute to Kenney—eponymous for the equine endometrial biopsy grading system—by reviewing the cedure. We present this review in three parts: 1) how observational data are acquired; 2) how these data are interpreted; and how these data are applied in equine reproduction science and medicine. 2011 Elsevier Inc. All rights reserved. words: Equine reproduction; Uterine biopsy; Endometrium; Endometrial score; Epicrisis ntents

Introduction .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1568

Observation .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1568 2.1. Need demonstrated .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1568 2.2. Instrumentation .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1568 2.3. Technique .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1569 2.4. Fixation .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1570 2.5. Staining .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1570 2.6. Indications and contra-indications .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1571 2.7. Histological surveys established .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1571 2.8. Effects on the reproductive cycle .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1571

Interpretation .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1572 3.1. Importance of ancillary data and artifacts .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1572 3.1.1. Effect of age and parity .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1572 3.1.2. Effect of estrus cycle and season ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1573 3.1.3. Artifacts .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1573 3.2. Histopathologic parameters assessed .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1573

Theriogenology 75 (2011) 1567–1581 www.theriojournal.comCorresponding author. Tel.: 405-744-8577; fax: 405-744-6265.

E-mail address: reed.holyoak@okstate.edu (G.R. Holyoak). 3-691X/$ – see front matter © 2011 Elsevier Inc. All rights reserved. :10.1016/j.theriogenology.2010.12.013 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4. . . . . . . . . pregn ... . . . . . . . . . . . . . . . . . . . . .

Ac .. . . . . . .

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W ind nu upon reproduction as a formally recognized specialty.

Thirdly and fourthly, the value of racing horses (Snider, 1568 T.A. Snider et al. / Theriogenology 75 (2011) 1567–1581Observation