Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorumNatural Product Research

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Authors
Mohamed N. Gomaa, Kawther Soliman, Ahmed Ayesh, Aida Abd El-Wahed, Zeinab Hamza, Hager M. Mansour, Shaden A.M. Khalifa, Hapipah Bint Mohd Ali, Hesham R. El-Seedi
Year
2015
DOI
10.1080/14786419.2015.1040991
Subject
Plant Science / Organic Chemistry / Analytical Chemistry / Biochemistry

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Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

Mohamed N. Gomaaa, Kawther Solimana, Ahmed Ayesha, Aida

Abd El-Wahedb, Zeinab Hamzac, Hager M. Mansourd, Shaden A.M.

Khalifae, Hapipah Bint Mohd Alif & Hesham R. El-Seedibef a Biology Department, Faculty of Science and Arts-Khulais, King

Abdulaziz University, Khulais, Saudi Arabia b Pharmacognosy Division, Department of Medicinal Chemistry,

Biomedical Centre, Uppsala University, Box 574, SE-751 24

Uppsala, Sweden c Marine Toxins Laboratory, Food Toxins and Contaminants

Department, National Research Centre, Dokki, Cairo, Egypt d H.E.J. Research Institute of Chemistry, International Center for

Chemical Sciences, University of Karachi, Karachi 75270, Pakistan e Department of Experimental Hematology, Karolinska University

Hospital, SE-141 86 Stockholm, Sweden f Centre for Natural Products and Drug Discovery (CENAR),

Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Published online: 17 Jul 2015.

To cite this article: Mohamed N. Gomaa, Kawther Soliman, Ahmed Ayesh, Aida Abd El-Wahed,

Zeinab Hamza, Hager M. Mansour, Shaden A.M. Khalifa, Hapipah Bint Mohd Ali & Hesham R. El-Seedi (2015): Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum, Natural Product

Research: Formerly Natural Product Letters, DOI: 10.1080/14786419.2015.1040991

To link to this article: http://dx.doi.org/10.1080/14786419.2015.1040991

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SHORT COMMUNICATION

Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

Mohamed N. Gomaaa, Kawther Solimana, Ahmed Ayesha, Aida Abd El-Wahedb,

Zeinab Hamzac, Hager M. Mansourd, Shaden A.M. Khalifae, Hapipah Bint Mohd Alif and Hesham R. El-Seedibef* aBiology Department, Faculty of Science and Arts-Khulais, King Abdulaziz University, Khulais, Saudi

Arabia; bPharmacognosy Division, Department of Medicinal Chemistry, Biomedical Centre, Uppsala

University, Box 574, SE-751 24 Uppsala, Sweden; cMarine Toxins Laboratory, Food Toxins and

Contaminants Department, National Research Centre, Dokki, Cairo, Egypt; dH.E.J. Research Institute of

Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan; eDepartment of Experimental Hematology, Karolinska University Hospital, SE-141 86 Stockholm, Sweden; fCentre for Natural Products and Drug Discovery (CENAR), Chemistry Department, Faculty of Science,

University of Malaya, 50603 Kuala Lumpur, Malaysia (Received 1 January 2015; final version received 2 April 2015)

The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus,

Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound antimicrobial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

Keywords: soft coral; Sarcophyton trocheliophorum; terpenoid; in vitro; antimicrobial assays q 2015 Taylor & Francis *Corresponding author. Email: hesham.el-seedi@fkog.uu.se

Natural Product Research, 2015 http://dx.doi.org/10.1080/14786419.2015.1040991

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Ju ly 20 15 1. Introduction

Soft corals such as the Coelenterates (class: Anthozoa, subclass: Octocorallia, order:

Alcyonacea, family: Alcyoniidae) have been studied extensively and produce a range of interesting compounds (Rˇezanka & Dembitsky 2001). Sarcophyton is one of the most commonly found soft corals in the tropical and sub-tropical oceans (Li et al. 2009). To date, around 30 species from this genus have been sampled and tested for bioactive secondary metabolites (Bie et al. 2008). Extracts from these species displayed a plethora of interesting pharmacological properties (Anjaneyulu & Rao 1997), including HIV inhibition, neuroprotective activity, cytotoxicity, anti-inflammatory activity (Lin et al. 2011a) and antimicrobial activity (Badria et al. 1997).